UROKINASE-PRODUCING TUMOR-GROWTH IN SCID MICE INHIBITED BY RECOMBINANT PAI-2

被引：8

作者：

ASTEDT, B

BILLSTROM, A

LECANDER, I

机构：

[1] Research Laboratory, the Department of Obstetrics and Gynaecology, University Hospital, Lund

来源：

FIBRINOLYSIS | 1995年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0268-9499(95)80008-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A u-PA-producing human prostatic tumour was inoculated into SCID mice, rPAI-2 being administered daily from day 8 after inoculation, when the solid tumours had become established. Repeated measurements of tumour size showed tumour growth to differ increasingly between the rPAI-2-treated and control groups, being significantly reduced in the treatment group at euthanisation on day 30, when mean tumour weight was only 0.509g in the rPAI-2 treated group, as compared to 1.309 in the control group. This tumour suppressive effect of rPAI-2 is probably due to its u-PA inhibitory property.

引用

页码：175 / 177

页数：3

共 17 条

[1] IMMUNOLOGICAL IDENTITY OF UROKINASE AND OVARIAN CARCINOMA PLASMINOGEN ACTIVATOR RELEASED IN TISSUE-CULTURE [J].