ORAL TROFOSFAMIDE - AN ACTIVE-DRUG IN THE TREATMENT OF SOFT-TISSUE SARCOMA

被引：30

作者：

BLOMQVIST, C

WIKLUND, T

PAJUNEN, M

VIROLAINEN, M

ELOMAA, I

机构：

[1] Department of Radiotherapy and Oncology, University of Helsinki, FIN-Helsinki 29

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1995年 / 36卷 / 03期

关键词：

SOFT-TISSUE SARCOMA; CHEMOTHERAPY TROFOSFAMIDE;

D O I：

10.1007/BF00685858

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 23 patients with metastatic sarcomas were treated with continuous oral trofosfamide, an alkylating agent structurally related to cyclophosphamide and ifosfamide. In all, 12 of the patients were chemotherapy-naive. Doses were escalated every 3rd week until the development of leukopenia of WHO grade 2. The treatment was well tolerated and produced little subjective toxicity. Leukopenia was the dose-limiting toxicity. The daily dose that produced grade 2 leukopenia was 200-250 mg in 65% of the patients. Three patients responded, all of whom had been treated with trofosfamide as first-line treatment.

引用

页码：263 / 265

页数：3

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