EFFECT OF ETHANOL ON MEMBRANES - FLUORESCENT-PROBE STUDY

被引：45

作者：

VANDERKOOI, JM

机构：

[1] Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1979年 / 3卷 / 01期

关键词：

D O I：

10.1111/j.1530-0277.1979.tb04770.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Using fluorescence techniques to study changes in membrane structure as a function of ethanol concentration and alcoholism, it was found that ethanol primarily affects probes located at the membrane‐water Interface. Changes in the lipid composition of membranes during alcoholism were detected by fluorescent probes that partition into the hydrophobic interior of the membrane. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：60 / 63

页数：4

共 4 条

[1] DRUG TOLERANCE IN BIOMEMBRANES - SPIN LABEL STUDY OF EFFECTS OF ETHANOL [J].

CHIN, JH ;

GOLDSTEIN, DB .

SCIENCE, 1977, 196 (4290) :684-685

[2] OXYGEN DIFFUSION IN BIOLOGICAL AND ARTIFICIAL MEMBRANES DETERMINED BY FLUOROCHROME PYRENE [J].

FISCHKOFF, S ;

VANDERKOOI, JM .

JOURNAL OF GENERAL PHYSIOLOGY, 1975, 65 (05) :663-676

[3] FLUORESCENT-PROBE ANALYSIS OF LIPID ARCHITECTURE OF NATURAL AND EXPERIMENTAL CHOLESTEROL-RICH MEMBRANES [J].

VANDERKOOI, J ;

FISCHKOFF, S ;

CHANCE, B ;

COOPER, RA .

BIOCHEMISTRY, 1974, 13 (08) :1589-1595

[4] INTERACTION OF GENERAL-ANESTHETICS WITH PHOSPHOLIPID VESICLES AND BIOLOGICAL-MEMBRANES [J].

VANDERKOOI, JM ;

LANDESBERG, R ;

SELICK, H ;

MCDONALD, GG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 464 (01) :1-16

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