PRODUCTION OF ANTIBODY TO TETANUS TOXOID BY CONTINUOUS HUMAN LYMPHOBLASTOID CELL LINES

被引：93

作者：

ZURAWSKI, VR ^{[1
]}

HABER, E ^{[1
]}

BLACK, PH ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,BOSTON,MA 02114

来源：

SCIENCE | 1978年 / 199卷 / 4336期

关键词：

D O I：

10.1126/science.204013

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with Epstein-Barr virus. Forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. Subcultures derived from limiting dilution experiments continued to secrete the antibody. Some of these antibody-secreting cells have been in continuous culture for more than 6 months. Copyright © 1978 AAAS.

引用

页码：1439 / 1441

页数：3

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