MICROVISCOSITY CHANGES DURING DIFFERENTIATION OF NEUROBLASTOMA-CELLS

被引：37

作者：

DELAAT, SW ^{[1
]}

VANDERSAAG, PT ^{[1
]}

ADNELEMANS, S ^{[1
]}

SHINITZKY, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT MEMBRANE RES,REHOVOT,ISRAEL

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1978年 / 509卷 / 01期

关键词：

D O I：

10.1016/0005-2736(78)90019-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microviscosity η of the plasma-membrane lipid matrix was measured in exponentially growing and differentiating C1300 mouse neuroblastoma cells, attached to a glass substratum, by fluorescence polarisation of 1,6-diphenyl-1,3,5-hexatriene. Upon differentiation η decreases progressively, reaching values below those observed in the growth phase. Treatment of the cells with dipalmitoyl phosphatidylcholine vesicles reversibly inhibits morphological differentiation. The results show that a high membrane fluidity is a prerequisite for differentiation. © 1978.

引用

页码：188 / 193

页数：6

共 8 条

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