DECREASED HALF-LIFE OF CYCLOPHOSPHAMIDE IN PATIENTS UNDER CONTINUAL TREATMENT

被引：68

作者：

DINCALCI, M

BOLIS, G

FACCHINETTI, T

MANGIONI, C

MORASCA, L

MORAZZONI, P

SALMONA, M

机构：

[1] IST RIC FARMACOL MARIO NEGRI, VIA ERITREA 62, I-20157 MILAN, ITALY

[2] CLIN OSTETRICA & GINECOLIA, MILAN, ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1979年 / 15卷 / 01期

关键词：

D O I：

10.1016/0014-2964(79)90198-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients. © 1979.

引用

页码：7 / 10

页数：4

共 19 条

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