CHEMICAL BEHAVIOR OF COENZYME PQQ TOWARD AMINOGUANIDINE - REDOX REACTION AND ADDUCT FORMATION

被引：14

作者：

MURE, M ^{[1
]}

NII, K ^{[1
]}

ITOH, S ^{[1
]}

OHSHIRO, Y ^{[1
]}

机构：

[1] OSAKA UNIV, FAC ENGN, DEPT APPL CHEM, YAMADAOKA 2-1, SUITA, OSAKA 565, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1990年 / 63卷 / 02期

关键词：

D O I：

10.1246/bcsj.63.417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of coenzyme PQQ with aminoguanidine, which is known as an inhibitor of quinoprotein amine oxidases, was investigated in vitro. The redox reaction predominantly proceeded at pH 10.0 to give PQQH2 (quinol), whereas deactivation of PQQ occurred at pH 6.7 to give the triazine adduct. In the case of semicarbazide or acetohydrazide as the substrate, azo adduct formation was mainly observed even at pH 10.0. Importance of the C-5 carbinolamine-type intermediate a is discussed.

引用

页码：417 / 420

页数：4

共 12 条

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