MULTIPLICATION STIMULATING ACTIVITY REGULATES ORNITHINE DECARBOXYLASE IN ISOLATED PORCINE GRANULOSA-CELLS INVITRO

被引：24

作者：

VELDHUIS, JD

HAMMOND, JM

机构：

[1] Department of Medicine, Division of Endocrinology, The Milton S. Hershey Medical Center The Pennsylvania State University, Hershey, PA

来源：

ENDOCRINE RESEARCH COMMUNICATIONS | 1979年 / 6卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07435807909061109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The polypeptide growth factor, multiplication stimulating activity (MSA), stimulates ornithine decarboxylase (ODC) activity in isolated porcine granulosa cells maintained under chemically defined conditions in vitro. The stimulatory action of MSA is saturable, and dose-dependent (0.1-1000 ng/ml). MSA effects are additive to those of luteinizing hormone (LH), but not those of follicle stimulating hormone (FSH). Stimulation of ODC activity by MSA requires cellular protein and RNA synthesis, and appears to be mediated independently of cyclic AMP. These observations provide the first demonstration of MSA action in the mammalian ovary. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：299 / 309

页数：11

共 20 条

[1]

BACHRACH U, 1978, ADV POLYAMINE RES, V1, P83

[2]

Channing C P, 1970, Recent Prog Horm Res, V26, P589

[3] MECHANISM OF ACTION OF LUTEINIZING-HORMONE AND FOLLICLE-STIMULATING-HORMONE ON OVARY INVITRO [J].

CHANNING, CP ;

TSAFRIRI, A .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1977, 26 (04) :413-468

[4] MULTIPLICATION-STIMULATING ACTIVITY FOR CHICKEN EMBRYO FIBROBLASTS FROM RAT-LIVER CELL CONDITIONED MEDIUM - FAMILY OF SMALL POLYPEPTIDES [J].

DULAK, NC ;

TEMIN, HM .

JOURNAL OF CELLULAR PHYSIOLOGY, 1973, 81 (02) :161-170

[5] PARTIALLY PURIFIED POLYPEPTIDE FRACTION FROM RAT-LIVER CELL CONDITIONED MEDIUM WITH MULTIPLICATION-STIMULATING ACTIVITY FOR EMBRYO FIBROBLASTS [J].

DULAK, NC ;

TEMIN, HM .

JOURNAL OF CELLULAR PHYSIOLOGY, 1973, 81 (02) :153-160

[6] FIBROBLAST AND EPIDERMAL GROWTH-FACTORS ARE MITOGENIC AGENTS FOR CULTURED GRANULOSA-CELLS OF RODENT, PORCINE, AND HUMAN-ORIGIN [J].

GOSPODAROWICZ, D ;

BIALECKI, H .

ENDOCRINOLOGY, 1979, 104 (03) :757-764

[7] INHIBITION OF ORNITHINE DECARBOXYLASE INVIVO IN RAT OVARY [J].

GUHA, SK ;

JANNE, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 75 (01) :136-142

[8]

LEDWITZRIGBY F, 1979, BIOL REPROD, V20, pA74

[9] EFFECTS OF NONSUPPRESSIBLE INSULIN-LIKE PROTEIN (NSILP) ON CYCLIC NUCLEOTIDE-METABOLISM IN RAT-LIVER [J].

LEICHTER, SB ;

POFFENBARGER, PL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 84 (02) :403-410

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

← 1 2 →