CALCITONIN - INHIBITORY EFFECT ON EATING IN RATS

被引：241

作者：

FREED, WJ

PERLOW, MJ

WYATT, RJ

机构：

来源：

SCIENCE | 1979年 / 206卷 / 4420期

关键词：

D O I：

10.1126/science.493987

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition offeeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system. Copyright © 1979 AAAS.

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页码：850 / 852

页数：3

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