GLUCOSYL PHOSPHOTRIESTERS OF NUCLEOSIDES - EXCHANGE MECHANISM OF TRANSMEMBRANE TRANSPORT AND APPLICATION TO 5-FLUORO-DEOXYURIDINE

被引：13

作者：

DEBOUZY, JC

HERVE, M

NEUMANN, JM

GOUYETTE, C

DUPRAZ, B

HUYNHDINH, T

机构：

[1] INST PASTEUR,CNRS,UNITE CHIM ORGAN 487,28 RUE DOCTEUR ROUX,F-75724 PARIS 15,FRANCE

[2] CRSSA,UNITE BIOPHYS,LA TRONCHE,FRANCE

[3] UNIV PARIS 13,F-93000 BOBIGNY,FRANCE

[4] CENS,SERV BIOPHYS,F-91191 GIF SUR YVETTE,FRANCE

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 11期

关键词：

D O I：

10.1016/0006-2952(90)90108-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The structure and membrane interactions of lipophilic glucosyi phosphotriester derivatives of thymidine and 5-fluoro-deoxy thymidine are investigated by NMR spectroscopy. The self-association of these molecules, found in different solvents, presents a diastereoisomeric effect which is also observed in the transmembrane transport inside large unilamellar vesicles. The influence of the hydrophobic chain and the nature of the nucleoside in the water-membrane exchange process is discussed. © 1990.

引用

页码：1657 / 1664

页数：8

共 14 条

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ABRAGAM A, 1961, PRINCIPLES NUCLEAR M

[2]

ALLYGER TT, 1979, BIOCHEMISTRY-US, V18, P5348

[3]

GREGORAKIS J, 1985, TARGETING DRUGS SYNT

[4] DIASTEREOISOMER INTERACTIONS OF LIQUID-PHASE ANTIPODES [J].