EPIDERMAL PROSTAGLANDINS AFTER TOPICAL APPLICATION OF A TUMOR PROMOTOR

被引：64

作者：

BRESNICK, E ^{[1
]}

MEUNIER, P ^{[1
]}

LAMDEN, M ^{[1
]}

机构：

[1] UNIV VERMONT, COLL MED, DEPT BIOCHEM, BURLINGTON, VT 05401 USA

来源：

CANCER LETTERS | 1979年 / 7卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0304-3835(79)80106-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The topical application of the promotor, 12-O-tetradecanoyl-13-acetate, on the shaved backs of mice was attended by a striking increase in the PGE concentration within epidermis as early as 1 h later. This increase peaked at 24 h but the prostaglandin value remained elevated for at least 48 h. PGF, on the other hand, showed only a modest increase in epidermis with a maximum at 12 h. By 48 h, the PGF concentration returned to normal. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：121 / 125

页数：5

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