A COMPUTER GENERATED MODEL OF ADENOSINE RECEPTORS RATIONALIZING BINDING AND SELECTIVITY OF RECEPTOR LIGANDS

被引：11

作者：

QUINN, RJ

DOOLEY, MJ

ESCHER, A

HARDEN, FA

JAYASURIYA, H

机构：

[1] Division of Science and Technology, Griffith University, Brisbane

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 05期

关键词：

D O I：

10.1080/07328319108047251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computer graphic analyses on a broad spectrum of adenosine receptor ligands has shown that both the A1 and A2 adenosine receptors have three binding sites. The spatial relationship of these three binding sites has been defined. Adenosine orientation at A1 and A2 is different.

引用

页码：1121 / 1124

页数：4

共 3 条

[1] N6-[2-(3,5-DIMETHOXYPHENYL)-2-(2-METHYLPHENYL)ETHYL]ADENOSINE AND ITS URONAMIDE DERIVATIVES - NOVEL ADENOSINE AGONISTS WITH BOTH HIGH-AFFINITY AND HIGH SELECTIVITY FOR THE ADENOSINE A2-RECEPTOR [J].