A HIGH INVOLVEMENT OF O2- POSSIBLY GENERATED IN INNER MEMBRANES FOR IRON-INDUCED MICROSOMAL LIPID-PEROXIDATION

被引：10

作者：

KOGA, S ^{[1
]}

NAKANO, M ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, PHOTON MED RES CTR, HAMAMATSU, SHIZUOKA 43131, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90858-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid peroxidation of and the O2- generation by rat liver microsomes in the presence of NADPH or both NADPH and Fe3+ were determined by thiobarbituric acid-reacting substance formation and by chemiluminescence intensities with a cypridina luciferin analog, 2-methyl-6-(p-methoxyphenyl)-3, 7-dihydroimidazo[1,2-a]pyrazin-3-one(MCLA), as a chemiluminescence probe. Judging from the experiments with various inhibitors on the O2- generation and the lipid peroxidation, O2- generated, at intramembranous site, by cytochrome P-450 system is considered to be highly involved in the iron-induced lipid peroxidation. © 1992.

引用

页码：1087 / 1093

页数：7

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