INCREASED SERUM APOLIPOPROTEIN(A) IN PATIENTS WITH CHRONIC-RENAL-FAILURE TREATED WITH CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS

被引：31

作者：

MURPHY, BG

MCNAMEE, P

DULY, E

HENRY, W

ARCHBOLD, P

TRINICK, T

机构：

[1] BELFAST CITY HOSP,DEPT MED,BELFAST BT9 7AD,ANTRIM,NORTH IRELAND

[2] BELFAST CITY HOSP,DEPT CLIN CHEM,BELFAST BT9 7AD,ANTRIM,NORTH IRELAND

[3] ULSTER HOSP,BELFAST,NORTH IRELAND

来源：

ATHEROSCLEROSIS | 1992年 / 93卷 / 1-2期

关键词：

CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD); APOLIPOPROTEIN(A); LIPOPROTEIN(A); CHOLESTEROL;

D O I：

10.1016/0021-9150(92)90199-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with end-stage renal failure (ESRF) on renal replacement therapy are at significantly increased risk of cardiovascular disease. To determine whether altered concentrations of apolipoprotein(a) (apo(a)), the plasminogen-like protein moiety of the atherogenic particle lipoprotein(a), contributed to this increased risk, apo(a) concentrations were measured in 48 non-diabetic patients with ESRF treated by continuous ambulatory peritoneal dialysis (CAPD) therapy and compared with 65 controls. Apo(a) concentration was increased in CAPD patients compared to controls (geometric mean 419 units/l versus 137 units/l; ratio of means 3.06 (95% CI 1.95-4.80). We conclude that CAPD patients have increased apo(a) concentrations which may contribute to their increased risk of cardiovascular disease.

引用

页码：53 / 57

页数：5

共 25 条

[1] THE ASSOCIATION BETWEEN SERUM LP(A) CONCENTRATIONS AND ANGIOGRAPHICALLY ASSESSED CORONARY ATHEROSCLEROSIS - DEPENDENCE ON SERUM LDL LEVELS [J].