LIPOPHILIC AND HYDROPHILIC ESTERS OF 4-ACETYL-2-(2-HYDROXYETHYL)-5,6-BIS(4-CHLOROPHENYL)-2H-PYRIDAZIN-3-ONEAS ANTIHYPERTENSIVE AGENTS

被引：11

作者：

FOGT, SW ^{[1
]}

SCOZZIE, JA ^{[1
]}

HEILMAN, RD ^{[1
]}

POWERS, LJ ^{[1
]}

机构：

[1] DIAMOND SHAMROCK CORP, TR EVANS RES CTR, PAINESVILLE, OH 44077 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1980年 / 23卷 / 12期

关键词：

D O I：

10.1021/jm00186a030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1445 / 1448

页数：4

共 6 条

[1]

ALBERTSON NF, 1962, ORG REACTIONS, V12, P205

[2] ANTIHYPERTENSIVE 5,6-DIARYLPYRIDAZIN-3-ONES [J].

BUCHMAN, R ;

SCOZZIE, JA ;

ARIYAN, ZS ;

HEILMAN, RD ;

RIPPIN, DJ ;

PYNE, WJ ;

POWERS, LJ ;

MATTHEWS, RJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) :1398-1405

[3]

KOVACH IM, 1975, J PHARM SCI, V64, P1070

[4] PYRIDINIUM POLYHYDROGEN FLUORIDE, A DEPROTECTING REAGENT IN PEPTIDE CHEMISTRY [J].

MATSUURA, S ;

NIU, CH ;

COHEN, JS .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1976, (12) :451-452

[5] SYNTHESIS OF PEPTIDES WITH RETAINED CONFIGURATION BY MEANS OF SOME ACID CHLORIDES [J].

TASCHNER, E ;

SMULKOWS.M ;

LUBIEWSK.L .

ANNALEN DER CHEMIE-JUSTUS LIEBIG, 1970, 739 :228-&

[6] ORALLY ACTIVE ESTERS OF CEPHALOSPORIN ANTIBIOTICS .3. SYNTHESIS AND BIOLOGICAL PROPERTIES OF AMINOACYLOXYMETHYL ESTERS OF 7-[D-(-)-MANDELAMIDO]-3-[[(1-METHYL-1H-TETRAZOL-5-YL)THIO]METHYL]-3-CEPHEM-4-CARBOXYLIC ACID [J].

WHEELER, WJ ;

PRESTON, DA ;

WRIGHT, WE ;

HUFFMAN, GW ;

OSBORNE, HE ;

HOWARD, DP .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (06) :657-661

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