BW-A522 BLOCKS ADENOSINE A(3) RECEPTOR-MEDIATED HYPOTENSIVE RESPONSES IN THE RAT

被引：29

作者：

FOZARD, JR

HANNON, JP

机构：

[1] Preclinical Research 386/510, Sandoz Pharma Ltd.

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 02期

关键词：

ADENOSINE A(3) RECEPTOR; APNEA (N-6-2-(4-AMINOPHENYL)ETHYL ADENOSINE); BW-A522;

D O I：

10.1016/0014-2999(94)90604-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)-1-propylxanthine (I-ABOPX; BW-A522), which has nanomolar affinity for the recently cloned human and sheep adenosine A(3) receptor, on the putative A(3) receptor mediated hypotensive response to N-6-2-(4-aminophenyl)ethyl adenosine (APNEA) in the rat have been investigated. Following blockade of A(1) and A(2) receptors with 8-(p-sulphophenyl)theophylline, BW-A522, 10 and 40 mg/kg i.v., blocked dose-dependently and surmountably the hypotensive response to APNEA. The results provide direct evidence of an A(3) receptor in the cardiovascular system of the rat which induces hypotension when activated.

引用

页码：R5 / R6

页数：2

共 7 条

[1] EFFECT OF PERTUSSIS TOXIN TREATMENT ON THE PUTATIVE ADENOSINE A3 RECEPTOR-MEDIATED HYPOTENSIVE RESPONSE IN THE RAT [J].