D-AMINO-ACID LEVELS IN HUMAN PHYSIOLOGICAL FLUIDS

被引：104

作者：

ARMSTRONG, DW ^{[1
]}

GASPER, M ^{[1
]}

LEE, SH ^{[1
]}

ZUKOWSKI, J ^{[1
]}

ERCAL, N ^{[1
]}

机构：

[1] KYUNGPOOK NATL UNIV,TAEGU 702701,SOUTH KOREA

来源：

CHIRALITY | 1993年 / 5卷 / 05期

关键词：

URINE; PLASMA; CEREBROSPINAL FLUID; AMNIOTIC FLUID; D-PIPECOLIC ACID;

D O I：

10.1002/chir.530050519

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Plasma, urine, cerebrospinal fluid (CSF), and amniotic fluid were examined to determine whether free D-amino acids were present and if so at what levels. It was found that D-amino acids exist in all physiological fluids tested, but that their level varied, considerably. The lowest levels of D-amino acids were usually found in amniotic fluid or CSF (almost always <1% of the corresponding L-amino acid). The highest levels were found in urine (usually tenth percent to low percent levels). Pipecolic acid seemed to be different from the other amino acids tested in that it was excreted primarily as the D-enantiomer (often >90%). Correspondingly high levels of D-pipecolic acid were not found in plasma. Some of the trends found in this work seemed to be analogous to those found in a recent rodent study. (C) 1993 Wiley-Liss, Inc.

引用

页码：375 / 378

页数：4

共 24 条

[1]

ARMSTRONG D W, 1991, Amino Acids (Vienna), V1, P97, DOI 10.1007/BF00808096

[2]

ARMSTRONG DW, 1993, AMINO ACIDS, V4, P402

[3]

ONTOGENY OF IMINOGLYCINE TRANSPORT IN MAMMALIAN KIDNEY [J].