ADMINISTRATION OF INACTIVATED AND DETERGENT-TREATED INFLUENZA-VIRUS TO MICE BEFORE VIRUS CHALLENGE REDUCES MORTALITY

被引：1

作者：

ARORA, DJS

机构：

[1] Virology Research Center, Institut Armand Frappier, Université du Québec, Laval, Québec, Laval des Rapides

来源：

JOURNAL OF MEDICAL VIROLOGY | 1993年 / 41卷 / 01期

关键词：

CHALLENGE; PROTECTION; INACTIVATED VIRUS; NK CELLS; PMNL;

D O I：

10.1002/jmv.1890410117

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Formalin-inactivated virus (FIV) and the detergent-treated virus (DTV) preparations were tested for their ability to enhance the resistance of mice to experimental influenza infection. FIV (100 mug) was administered intravenously to mice. After 24 hr, animals were challenged with 5 LD50 dose intranasally. FIV-treated and non-treated (control) mice had 10% and 100% mortality, respectively. Similar results were obtained with the DTV (40 mug) preparation. The pulmonary virus titer of FIV-treated mice was lower when compared with the control. Mechanisms other than acquired immunity may have conferred the early resistance to virus infection in mice. (C) 1993 Wiley-Liss, Inc.

引用

页码：85 / 89

页数：5

共 31 条

[1]

ARORA DJS, 1988, NAT IMMUN CELL GROW, V7, P287

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