ENHANCED AGGRESSIVE-BEHAVIOR IN MICE LACKING 5-HT1B RECEPTOR

被引：662

作者：

SAUDOU, F ^{[1
]}

AMARA, DA ^{[1
]}

DIERICH, A ^{[1
]}

LEMEUR, M ^{[1
]}

RAMBOZ, S ^{[1
]}

SEGU, L ^{[1
]}

BUHOT, MC ^{[1
]}

HEN, R ^{[1
]}

机构：

[1] CNRS, RECH NEUROSCI GRP, EQUIPE MEMOIRE & RECEPTEURS, F-13402 MARSEILLE 20, FRANCE

来源：

SCIENCE | 1994年 / 265卷 / 5180期

关键词：

D O I：

10.1126/science.8091214

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/(1B) agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.

引用

页码：1875 / 1878

页数：4

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