RECEPTOR TO NUCLEUS SIGNALING VIA TYROSINE PHOSPHORYLATION OF THE P91 TRANSCRIPTION FACTOR

被引：14

作者：

DALY, C

REICH, NC

机构：

[1] Christopher Daly and Nancy C. Reich are, the Department of Pathology, State University of New York, Stony Brook

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/1043-2760(94)90013-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies on Signal transduction stimulated by interferons have defined pathways chat link cell surface receptors to target genes in the nucleus. After interferon binding nonreceptor tyrosine kinases are activated that phosphorylate components of latent DNA-binding factors in the cytoplasm. These phosphorylated factors form multimeric complexes that translocate to the nucleus and bind to specific DNA sequences in the promoters of induced genes. A 91-kD factor (p91 or Stat91) is activated by interferons and serves as a subunit partner in the composition of diverse transcription factors.

引用

页码：159 / 164

页数：6

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