A NOVEL POINT MUTATION OF THE RET PROTOONCOGENE IN SMALL-CELL LUNG-CARCINOMA CELL-LINES

被引：11

作者：

FUTAMI, H

EGAWA, S

YAMAGUCHI, K

机构：

[1] Growth Factor Division, National Cancer Center Research Institute, Tokyo, 5-1-1 Tsukiji, Chuo-ku

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1994年 / 70卷 / 10期

关键词：

SMALL CELL LUNG CARCINOMA; RET; POINT MUTATION; MULTIPLE ENDOCRINE NEOPLASIA; MEDULLARY THYROID CARCINOMA;

D O I：

10.2183/pjab.70.210

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Point mutations of the RET proto-oncogene are associated with the development of inherited diseases including multiple endocrine neoplasia (MEN) type 2, familial medullary thyroid carcinoma (MTC), and Hirschsprung's disease as well as a part of sporadic MTCs and pheochromocytomas. In the present study, we examined point mutations of the RET proto-oncogene in exons 10, 11 and 16 in small cell lung carcinoma (SCLC) cell lines. A novel point mutation from GCC to GAC at codon 664 in exon 11 was identified in 2 out of 6 SCLC cell lines; this alteration results in an amino acid substitution of aspartic acid for alanine. This point mutation was not detected in other types of cancer cell lines so far examined. Point mutations of the RET proto-oncogene reported previously in exons 10, 11 and 16 in above-mentioned diseases were not detected in the SCLC cell lines. These results suggest that this point mutation of the RET proto-oncogene is closely associated with a part of SCLC.

引用

页码：210 / 214

页数：5

共 20 条

[1] MOLECULAR CHARACTERIZATION OF A THYROID TUMOR-SPECIFIC TRANSFORMING SEQUENCE FORMED BY THE FUSION OF RET TYROSINE KINASE AND THE REGULATORY SUBUNIT RI-ALPHA OF CYCLIC AMP-DEPENDENT PROTEIN KINASE-A [J].