FREQUENT LAMBDA-LIGHT CHAIN GENE REARRANGEMENT AND EXPRESSION IN A LY-1 B-LYMPHOMA WITH A PRODUCTIVE KAPPA-CHAIN ALLELE

被引：93

作者：

HARDY, RR ^{[1
]}

DANGL, JL ^{[1
]}

HAYAKAWA, K ^{[1
]}

JAGER, G ^{[1
]}

HERZENBERG, LA ^{[1
]}

机构：

[1] STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1986年 / 83卷 / 05期

关键词：

D O I：

10.1073/pnas.83.5.1438

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe here a murine Ly-1-bearing pre-B-cell tumor that, when induced for .kappa. light chain expression with bacterial lipopolysaccharide, also gives rise spontaneously to a few percent of cells expressing surface .lambda. light chains. These .lambda.-positive cells have undergone DNA rearrangements involving either V.lambda. or V.lambda.2 genes. Nearly all clones of .lambda.-bearing cells express .mu. and .lambda. on their surface (but not .kappa.). However, all these .lambda.-positive clones continue to transcribed .kappa. mRNA and synthesize internal .kappa. chains. Further, surface .lambda.-positive clones show JH rearrangements on one or both heavy chain chromosomes.

引用

页码：1438 / 1442

页数：5

共 35 条

[1] ACTIVITY OF MULTIPLE LIGHT CHAIN GENES IN MURINE MYELOMA CELLS PRODUCING A SINGLE, FUNCTIONAL LIGHT CHAIN [J].