SUPPRESSION OF CHONDROGENIC EXPRESSION IN MIXTURES OF NORMAL CHONDROCYTES AND BUDR-ALTERED CHONDROCYTES GROWN IN VITRO

被引：34

作者：

CHACKO, S

HOLTZER, S

HOLTZER, H

机构：

[1] Department of Anatomy School of Medicine, University of Pennsylvania, Philadelphia, PA

[2] Department of Pathology School of Medicine, University of Pennsylvania, Philadelphia, PA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 34卷 / 02期

关键词：

D O I：

10.1016/0006-291X(69)90629-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When normal chondrocytes are mixed with suspended liver, or kidney, or muscle cells and reared in monolayers in vitro, the heteretypic cells suppress the synthesis of chendroitin sulfate by adjacent chondrecytes. Chondrecytes grown in BudR, though replicating normally, do not synthesize chondroitin sulfate. BudR-altered chondrocytes exhibit cell surface properties very different from those exhibited by functional chondrecytes. BudR-altered cells do not adhere to one another and they are amoeboid. In mixtures of BudR-altered chondrocytes and normal chondrecytes, the former cells function as heterotypic cells: BudR-altered cells suppress chondreitin sulfate synthesis by contiguous normal chondrecytes. © 1969.

引用

页码：183 / &

共 18 条

[1] LOSS OF PHENOTYPIC TRAITS BY DIFFERENTIATED CELLS .V. EFFECT OF 5-BROMODEOXYURIDINE ON CLONED CHONDROCYTES [J].