DRUG-EXCIPIENT INCOMPATIBILITY STUDIES OF THE DIPEPTIDE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR, MOEXIPRIL HYDROCHLORIDE - DRY POWDER VS WET GRANULATION

被引：45

作者：

GU, L

STRICKLEY, RG

CHI, LH

CHOWHAN, ZT

机构：

[1] Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 04期

关键词：

incompatibility screen; moexipril; solid state; stability;

D O I：

10.1023/A:1015871406549

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The drug-excipient incompatibility screen for moexipril hydrochloride 1 using various isothermal stress methods is reported herein. It was found that most of the commonly used fillers, disintegrants, lubricants, glidants, and coating agents were incompatible with 1 in dry powder mixtures; moisture and basic (or alkalizing) agents were determined to be the dominant destabilizing factors. In wet granulations, basic agents, however, were found to suppress drug degradation even in the presence of moisture. Supported by the product distribution studies, the stabilization is proposed to involve the neutralization of the acidic drug by the basic excipients. © 1990, Plenum Publishing Corporation. All rights reserved.

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收藏

页码：379 / 383

页数：5

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