DENDRITIC SPINE DENSITY OF ADULT HIPPOCAMPAL PYRAMIDAL CELLS IS SENSITIVE TO THYROID-HORMONE

被引:88
作者
GOULD, E
ALLAN, MD
MCEWEN, BS
机构
[1] Laboratory of Neuroendocrinology, The Rockefeller University, New York
关键词
CA1; region; Dendritic spine; Golgi impregnation; Hippocampus; Pyramidal cell; Thyroid hormone;
D O I
10.1016/0006-8993(90)90884-E
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In order to determine whether pyramidal cells of the adult hippocampus are morphologically sensitive to thyroid hormone, we performed single-section Golgi impregnation analyses on brains from hyperthyroid and control rats. Quantitative analyses of Golgi-impregnated pyramidal cells from the CA1 region showed a significant decrease in the density of apical dendritic spines with hyperthyroidism. In contrast, no changes were observed in spine density of basal dendrites or in cross-sectional cell body area of CA1 pyramidal cells. No changes in any of these morphological variables were detected in pyramidal cells of the CA3 region with hyperthyroidism. These results suggest that spine density of the apical dendrites of CA1 pyramidal cells is specifically affected by thyroid hormone in adulthood. Since dendritic spines are thought to represent postsynaptic sites it is likely that this morphological change results in altered hippocampal function. © 1990.
引用
收藏
页码:327 / 329
页数:3
相关论文
共 14 条
  • [1] EAYRS J. T., 1964, ARCH BIOL, V75, P529
  • [2] THE SINGLE SECTION GOLGI-IMPREGNATION PROCEDURE - METHODOLOGICAL DESCRIPTION
    GABBOTT, PL
    SOMOGYI, J
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 1984, 11 (04) : 221 - 230
  • [3] GOULD E, 1990, J NEUROSCI, V10, P996
  • [4] GOULD E, 1989, J NEUROSCI, V9, P3347
  • [5] GOULD E, 1990, J NEUROSCI, V10, P1286
  • [6] TRIIODOTHYRONINE (T3) INDUCES NEURITE FORMATION AND INCREASES SYNTHESIS OF A PROTEIN RELATED TO MAP 1B IN CULTURED-CELLS OF NEURONAL ORIGIN
    HARGREAVES, A
    YUSTA, B
    ARANDA, A
    AVILA, J
    PASCUAL, A
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 1988, 38 (01): : 141 - 148
  • [7] INFRAPYRAMIDAL MOSSY FIBERS IN THE HIPPOCAMPUS OF THE HYPER-THYROID RAT - A LIGHT AND ELECTRON-MICROSCOPIC STUDY
    LAUDER, JM
    MUGNAINI, E
    [J]. DEVELOPMENTAL NEUROSCIENCE, 1980, 3 (4-6) : 248 - 265
  • [8] NEUROLOGICAL ABNORMALITIES IN PATIENTS TREATED FOR HYPO-THYROIDISM FROM EARLY LIFE
    MACFAUL, R
    DORNER, S
    BRETT, EM
    GRANT, DB
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1978, 53 (08) : 611 - 619
  • [9] MAHLER ME, 1987, WESTERN J MED, V146, P705
  • [10] Olton D.S., 1983, NEUROBIOLOGY HIPPOCA, P335