CHARACTERIZATION OF 4 NOVEL RAS-LIKE GENES EXPRESSED IN A HUMAN TERATOCARCINOMA CELL-LINE

被引：290

作者：

DRIVAS, GT

SHIH, A

COUTAVAS, E

RUSH, MG

DEUSTACHIO, P

机构：

[1] NYU, SCH MED, DEPT BIOCHEM, NEW YORK, NY 10016 USA

[2] NYU, SCH MED, KAPLAN CANC CTR, NEW YORK, NY 10016 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 04期

关键词：

D O I：

10.1128/MCB.10.4.1793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.

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页码：1793 / 1798

页数：6

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