SYNTHESIS AND BETA-BLOCKING ACTIVITY OF (E)-IMINOETHERS AND (Z)-IMINOETHERS OF 1,8-NAPHTHYRIDINE - POTENTIAL ANTIHYPERTENSIVE AGENTS .4.

被引：19

作者：

FERRARINI, PL ^{[1
]}

MORI, C ^{[1
]}

PRIMOFIORE, G ^{[1
]}

DASETTIMO, A ^{[1
]}

BRESCHI, MC ^{[1
]}

MARTINOTTI, E ^{[1
]}

NIERI, P ^{[1
]}

CIUCCI, MA ^{[1
]}

机构：

[1] UNIV PISA,IST POLICATTEDRA DISCIPLINE BIOL,I-56100 PISA,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 06期

关键词：

1,8-naphthyridine derivatives; iminoethers; β-blockers;

D O I：

10.1016/0223-5234(90)90143-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of substituted (E)-and (Z)-iminoethers of 1,8-naphthyridine was synthesized from corresponding ketones. The pharmacological activity of these compounds was evaluated on isolated preparations to assess the eventual interaction with α and β adrenoceptors. All the compounds exhibited β2 stimulating and β1 blocking properties, while on α receptors neither stimulating nor blocking activity was observed. © 1990.

引用

页码：489 / 496

页数：8

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