APPLICATION OF AN OVOMUCOID-CONJUGATED POLYMER COLUMN FOR THE ENANTIOSPECIFIC DETERMINATION OF CHLORPRENALINE CONCENTRATIONS IN PLASMA

被引：10

作者：

MIWA, T

SAKASHITA, S

OZAWA, H

HAGINAKA, J

ASAKAWA, N

MIYAKE, Y

机构：

[1] MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,NISHINOMIYA,HYOGO 663,JAPAN

[2] EISAI & CO LTD,RES DEPT 4,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 566卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80121-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An ovomucoid-conjugated polymer column was prepared for the liquid chromatographic resolution of racemic compounds. The column showed strong retention of acidic solutes, a characteristic attributed to the structure of the stationary phase support gel. Although the efficiency of the column was lower than that of an ovomucoid-conjugated silica gel column, enantiospecific chlorprenaline determination in plasma was achieved with solute amounts from 1.0 ng to 0.1-mu-g.

引用

页码：163 / 171

页数：9

共 8 条

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