MELANOCYTE CHANGES FOLLOWING PUVA THERAPY

被引：40

作者：

ZELICKSON, AS

MOTTAZ, JH

MULLER, SA

机构：

[1] Departments of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota

[2] Mayo Clinic, Rochester, Minnesota

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1979年 / 1卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0190-9622(79)70034-X

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The effect of psoralens and long-wave ultraviolet light (PUVA) therapy on human melanocytes was studied at the ultrastructural level. The results demonstrate an increase in the number of melanocytes, a change in their location, and an increase in the size of the melanosomes. Significantly, some of the melanocytes extend in narrow columns deep into the dermis, limited by the basal lamina, while others are found free within the dermis. Other morphologic alterations in the melanocytes consist of abnormal mitochondria, a swollen and distorted endoplasmic reticulum, and large lysosomes. The aforementioned abnormalities were also present in PUVA-treated skin that was examined 15 months after the treatment had been stopped. © 1979, American Academy of Dermatology, Inc.. All rights reserved.

引用

页码：422 / 430

页数：9

共 10 条

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