ACTIVATION OF PHOSPHATIDYLINOSITOL LIPID-SPECIFIC PHOSPHOLIPASE C-BETA-3 BY G-PROTEIN BETA-GAMMA SUBUNITS

被引：79

作者：

CAROZZI, A

CAMPS, M

GIERSCHIK, P

PARKER, PJ

机构：

[1] IMPERIAL CANC RES FUND,PROT PHOSPHORYLAT LAB,LINCOLNS INN FIELDS,LONDON WC2A 3PX,ENGLAND

[2] GERMAN CANC RES CTR,DIV MOLEC PHARMACOL,W-6900 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1993年 / 315卷 / 03期

关键词：

PHOSPHOLIPASE-C ACTIVATION; G-PROTEIN BETA-GAMMA SUBUNIT; TRANSDUCIN;

D O I：

10.1016/0014-5793(93)81190-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel member of the inositol lipid-specific phospholipase C family, PtdIns-PLCbeta3, is shown to be activated by betagamma subunits of the heterotrimeric GTP-binding protein, transducin. The activation is a direct effect since it is observed with the purified proteins. Furthermore, the activation is blocked by the GDP-liganded alpha subunit of transducin, confirming that the effect is due to free betagamma subunits. The implications with respect to receptor-PtdIns-PVC coupling are discussed.

引用

页码：340 / 342

页数：3

共 10 条

[1] STIMULATION OF PHOSPHOLIPASE-C BY GUANINE-NUCLEOTIDE-BINDING PROTEIN-BETA-GAMMA SUBUNITS [J].