DOES MODULATION OF GLUTAMATERGIC FUNCTION REPRESENT A VIABLE THERAPEUTIC STRATEGY IN ALZHEIMERS-DISEASE

被引：62

作者：

LAWLOR, BA ^{[1
]}

DAVIS, KL ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED, DEPT PSYCHIAT, NEW YORK, NY 10029 USA

来源：

BIOLOGICAL PSYCHIATRY | 1992年 / 31卷 / 04期

关键词：

D O I：

10.1016/0006-3223(92)90227-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although glutamate dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD), it is unclear which direction a glutamatergic strategy should take in this illness. Increasing glutamate function may enhance excitotoxicity and neuronal death, whereas decreasing activity in this excitatory amino acid pathway may impair memory processes. Pharmacological modulation of the different NMDA and nonNMDA receptor sites, together with the concept of an agonist versus antagonist approach, are discussed in this review. It would appear that a glutamatergic approach may represent a new and exciting option to pursue in the experimental pharmacotherapeutics of AD.

引用

页码：337 / 350

页数：14

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