THE EFFECT OF CHRONIC CLOZAPINE ON BASAL DOPAMINE RELEASE AND APOMORPHINE-INDUCED DA RELEASE IN THE STRIATUM AND NUCLEUS-ACCUMBENS AS MEASURED BY INVIVO BRAIN MICRODIALYSIS

被引：8

作者：

CHAI, BL ^{[1
]}

MELTZER, HY ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,BIOL PSYCHOL LAB,CLEVELAND,OH 44106

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 01期

关键词：

CLOZAPINE; DOPAMINE; STRIATUM; NUCLEUS ACCUMBENS; APOMORPHINE; MICRODIALYSIS;

D O I：

10.1016/0304-3940(92)90678-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study. parenteral chronic clozapine (20 mg/kg/day for 21 days. i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100-mu-g/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.

引用

页码：47 / 50

页数：4

共 19 条

[1] CHRONIC TREATMENT WITH CLASSICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS DIFFERENTIALLY DECREASES DOPAMINE RELEASE IN STRIATUM AND NUCLEUS-ACCUMBENS INVIVO [J].

BLAHA, CD ;

LANE, RF .

NEUROSCIENCE LETTERS, 1987, 78 (02) :199-204

[2] ACUTE AND CHRONIC HALOPERIDOL TREATMENT - COMPARISON OF EFFECTS ON NIGRAL DOPAMINERGIC CELL ACTIVITY [J].

BUNNEY, BS ;

GRACE, AA .

LIFE SCIENCES, 1978, 23 (16) :1715-1727

[3] CHRONIC TREATMENT WITH CLOZAPINE SELECTIVELY DECREASES BASAL DOPAMINE RELEASE IN NUCLEUS-ACCUMBENS BUT NOT IN CAUDATE-PUTAMEN AS MEASURED BY INVIVO BRAIN MICRODIALYSIS - FURTHER EVIDENCE FOR DEPOLARIZATION BLOCK [J].

CHEN, JP ;

PAREDES, W ;

GARDNER, EL .

NEUROSCIENCE LETTERS, 1991, 122 (01) :127-131

[4]

CHIODO LA, 1983, J NEUROSCI, V3, P1607

[5]

CHIODO LA, 1985, J NEUROSCI, V5, P2539

[6] DOPAMINERGIC-CHOLINERGIC INTERACTIONS IN THE STRIATUM - THE CRITICAL SIGNIFICANCE OF CALCIUM CONCENTRATIONS IN BRAIN MICRODIALYSIS [J].

DEBOER, P ;

DAMSMA, G ;

FIBIGER, HC ;

TIMMERMAN, W ;

DEVRIES, JB ;

WESTERINK, BHC .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1990, 342 (05) :528-534

[7]

GRACE AA, 1986, J PHARMACOL EXP THER, V238, P1092

[8] APOMORPHINE DOES NOT REVERSE REDUCED BASAL DOPAMINE RELEASE IN RAT STRIATUM AND NUCLEUS ACCUMBENS AFTER CHRONIC HALOPERIDOL TREATMENT [J].

ICHIKAWA, J ;

MELTZER, HY .

BRAIN RESEARCH, 1990, 507 (01) :138-142

[9]

ICHIKAWA J, 1991, J PHARMACOL EXP THER, V256, P348

[10]

ICHIKAWA J, 1990, EUR J PHARMACOL, V176, P317

← 1 2 →