ENANTIOSPECIFIC SYNTHESIS OF AMINO-ACIDS - PREPARATION OF (R)-ALPHA-METHYLASPARTIC AND (S)-ALPHA-METHYLASPARTIC ACID FROM (S)-TRYPTOPHAN

被引：30

作者：

CHAN, CO

CRICH, D

NATARAJAN, S

机构：

[1] UNIV ILLINOIS,DEPT CHEM MC111,CHICAGO,IL 60680

[2] UNIV LONDON UNIV COLL,DEPT CHEM,LONDON WC1H 0AJ,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)92648-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiospecific synthesis of both antipodes of alpha-methylaspartic acid from (S)-tryptophan is described with the key steps being alkylation of the hexahydropyrroloindole 4, oxidative degradation of indoles and, for the preparation of the (R)-isomer, Barton reductive decarboxylation.

引用

页码：3405 / 3408

页数：4

共 31 条

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