(2R, 3R, 5S)-5-CARBOXALDEHYDE-2,3-DIPHENYL-1,4-DIOXANE AND (2R, 3R, 5R)-5-CARBOXALDEHYDE-2,3-DIPHENYL-1,4-DIOXANE AS SURROGATES FOR OPTICALLY PURE 2,3-O-ISOPROPYLIDENEGLYCERALDEHYDE IN ASYMMETRIC-SYNTHESIS

被引：16

作者：

AUBE, J

MOSSMAN, CJ

DICKEY, S

机构：

[1] Department of Medicinal Chemistry University of Kansas, Lawrence

来源：

TETRAHEDRON | 1992年 / 48卷 / 45期

关键词：

D O I：

10.1016/S0040-4020(01)92276-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds were prepared from threo-hydrobenzoin, either enantiomer of which is readily available from trans-stilbene using the Sharpless asymmetric dihydroxylation reaction. Several organometallic reagents were added to the aldehydes and the resulting adducts treated with H-2-Pd/C to give diastereomerically and enantiomerically enriched 1,2,3-triol-containing building blocks for asymmetric synthesis.

引用

收藏

页码：9819 / 9826

页数：8

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