SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF ABT-200 - A PUTATIVE NOVEL ANTIDEPRESSANT COMBINING POTENT ALPHA-2 ANTAGONISM WITH MODERATE NE UPTAKE INHIBITION

被引：16

作者：

ZELLE, RE ^{[1
]}

HANCOCK, AA ^{[1
]}

BUCKNER, SA ^{[1
]}

BASHA, FZ ^{[1
]}

TIETJE, K ^{[1
]}

DEBERNARDIS, JF ^{[1
]}

MEYER, MD ^{[1
]}

机构：

[1] ABBOTT LABS,PHARMACEUT DISCOVERY D47C,ABBOTT PK,IL 60064

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80353-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

ABT-200, (+/-)-(1'R*, 3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylenedioxy-1'-naphthalenyl)methyl]pyrrolidine, (1a/b) represents the first example of a new structural class of potent alpha-2 antagonists which possess the additional property of norepinephrine (NE) uptake inhibition. This profile of combined activities is expected to have utility in the treatment of depression.

引用

页码：1319 / 1322

页数：4

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