COMPLEXES OF ERGOT ALKALOIDS AND DERIVATIVES .I. INTERACTION OF CAFFEINE WITH ERGOTAMINE TARTRATE IN AQUEOUS SOLUTION

被引：24

作者：

ZOGLIO, MA

MAULDING, HV

WINDHEUSER, JJ

机构：

[1] Pharmacy Research and Development Department of Sandoz Pharmaceuticals, Hanover, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 02期

关键词：

Caffeine‐ergotamine tartrate—interaction; Dissolution rate; ergotamine tartrate—caffeine effect; Ergot alkaloids; derivatives—complexes; Partition rates; pH effect—ergotamine tartrate solubility;

D O I：

10.1002/jps.2600580218

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The interaction between ergotamine tartrate and caffeine was studied in distilled water, at pH 1 and at pH 6.65 with marked changes in solubility of the alkaloid being observed with increased caffeine concentration. Caffeine enhanced the dissolution rate of ergotamine tartrate by a factor of three at gastric pH. The partitioning rate of ergotamine tartrate from an aqueous to an organic phase was influenced by caffeine. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：222 / +

页数：1

共 7 条

[1] ALLPORT NJ, 1932, QUART J PHARM PHARMA, V5, P341
[2] BERCALL NICHOLAS A., 1950, CALIFORNIA MED, V72, P234
[3] BRODIE B, 1959, J PHARMACOL, V9, P345
[4] THE DISSOLUTION AND DIFFUSION OF ASPIRIN IN AQUEOUS MEDIA
EDWARDS, LJ
[J]. TRANSACTIONS OF THE FARADAY SOCIETY, 1951, 47 (11): : 1191 - 1210
[5] TREATMENT OF MIGRAINE
FRIEDMAN, AP
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1954, 250 (14) : 600 - 602
[6] URINARY EXCRETION KINETICS FOR EVALUATION OF DRUG ABSORPTION .1. SOLUTION RATE LIMITED AND NONSOLUTION RATE LIMITED ABSORPTION OF ASPIRIN AND BENZYL PENICILLIN - ABSORPTION RATE OF SULFAETHYLTHIADIAZOLE
NELSON, E
SCHALDEMOSE, I
[J]. JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1959, 48 (09): : 489 - 495
[7] INFLUENCE OF DISSOLUTION RATE AND SURFACE ON TETRACYCLINE ABSORPTION
NELSON, E
[J]. JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1959, 48 (02): : 96 - 103

← 1 →