ABSOLUTE-CONFIGURATION OF ACENOCOUMARIN

被引：21

作者：

WHEELER, CR ^{[1
]}

TRAGER, WF ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PHARMACEUT SCI, SEATTLE, WA 98195 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 09期

关键词：

D O I：

10.1021/jm00195a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The absolute configuration of acenocoumarin is assigned by chemical conversion of (-)-acenocoumarin to (S)-(-)-warfarin through a series of reactions not involving the asymmetric center. © 1979, American Chemical Society. All rights reserved.

引用

页码：1122 / 1124

页数：3

共 22 条

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[3] BRECKENRIDGE A, 1974, CLIN PHARMACOL THER, V15, P424
[4] BIOTRANSFORMATION AND PHARMACOKINETICS OF ACENOCOUMAROL (SINTROM) IN MAN
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[6] HERMODSON MA, 1971, J MED CHEM, V14, P167
[7] PLASMA HALF-LIVES, PLASMA METABOLITES AND ANTICOAGULANT EFFICACIES OF ENANTIOMERS OF WARFARIN IN MAN
HEWICK, DS
MCEWEN, J
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (06) : 458 - 465
[8] PLASMA HALF-LIVES OF ENANTIOMERS OF WARFARIN IN WARFARIN-RESISTANT AND WARFARIN-SUSCEPTIBLE RATS
HEWICK, DS
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1972, 24 (08) : 661 - &
[9] JAHNCHEN E, 1976, CLIN PHARMACOL THER, V20, P342
[10] LEVY G, 1974, RES COMMUN CHEM PATH, V7, P359

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