3 DIFFERENT CLASSES OF HUMAN ADENOVIRUS TRANSFORMING DNA SEQUENCES - HIGHLY ONCOGENIC SUBGROUP-A-SPECIFIC, WEAKLY ONCOGENIC SUBGROUP B-SPECIFIC, AND SUBGROUP C-SPECIFIC TRANSFORMING DNA SEQUENCES

被引:29
作者
FUJINAGA, K
SAWADA, Y
SEKIKAWA, K
机构
[1] Department of Molecular Biology, Cancer Research Institute, Sapporo Medical College, Sapporo
关键词
D O I
10.1016/0042-6822(79)90261-7
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
DNA-DNA homology measurements showed the presence of three different classes of human adenovirus transforming gene sequences: one specific for highly oncogenic subgroup A (types 12, 18, and 31), the second specific for weakly oncogenic subgroup B (types 3, 7, and 16), and the third specific for transforming subgroup C (types 2, 5, and 6). Adenovirus transforming DNA sequences with molecular weights of 1.6-1.8 × 106 are in common or almost identical among members within the same subgroup. Less than one-third of the transforming DNA sequences are shared among members of different subgroups. All of the DNA fragments containing transforming DNA sequences investigated are located at the end of the molecule. © 1979.
引用
收藏
页码:578 / 581
页数:4
相关论文
共 15 条