QUINOLINATE DIFFERENTIATES BETWEEN FOREBRAIN AND CEREBELLAR NMDA RECEPTORS

被引:79
作者
MONAGHAN, DT [1 ]
BEATON, JA [1 ]
机构
[1] UNIV NEBRASKA,MED CTR,DEPT INTERNAL MED,DIV NEUROL,OMAHA,NE 68198
关键词
AUTORADIOGRAPHY; NMDA RECEPTORS; QUINOLINATE; CEREBELLUM;
D O I
10.1016/0014-2999(91)90134-C
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [H-3]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (K(i) = 24 and 275-mu-M; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.
引用
收藏
页码:123 / 125
页数:3
相关论文
共 10 条
[1]   REPLICATION OF THE NEUROCHEMICAL CHARACTERISTICS OF HUNTINGTONS-DISEASE BY QUINOLINIC ACID [J].
BEAL, MF ;
KOWALL, NW ;
ELLISON, DW ;
MAZUREK, MF ;
SWARTZ, KJ ;
MARTIN, JB .
NATURE, 1986, 321 (6066) :168-171
[2]  
COTMAN CW, 1989, J NIH RES, V1, P65
[3]   DUAL-COMPONENT NMDA RECEPTOR CURRENTS AT A SINGLE CENTRAL SYNAPSE [J].
DANGELO, E ;
ROSSI, P ;
GARTHWAITE, J .
NATURE, 1990, 346 (6283) :467-470
[4]  
EHLERT FJ, 1990, J PHARMACOL EXP THER, V255, P1148
[5]   ON THE EXCITOTOXIC PROPERTIES OF QUINOLINIC ACID, 2,3-PIPERIDINE DICARBOXYLIC-ACIDS AND STRUCTURALLY RELATED-COMPOUNDS [J].
FOSTER, AC ;
COLLINS, JF ;
SCHWARCZ, R .
NEUROPHARMACOLOGY, 1983, 22 (12) :1331-&
[6]  
HEYES MP, 1989, ANN NEUROL, V26, P275
[7]   2 CLASSES OF N-METHYL-D-ASPARTATE RECOGNITION SITES - DIFFERENTIAL DISTRIBUTION AND DIFFERENTIAL REGULATION BY GLYCINE [J].
MONAGHAN, DT ;
OLVERMAN, HJ ;
NGUYEN, L ;
WATKINS, JC ;
COTMAN, CW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9836-9840
[8]   QUINOLINIC ACID - REGIONAL VARIATIONS IN NEURONAL SENSITIVITY [J].
PERKINS, MN ;
STONE, TW .
BRAIN RESEARCH, 1983, 259 (01) :172-173
[9]  
SEKIGUCHI M, 1990, J NEUROSCI, V10, P2148
[10]   NMDA RECEPTORS AND LIGANDS IN THE VERTEBRATE CNS [J].
STONE, TW ;
BURTON, NR .
PROGRESS IN NEUROBIOLOGY, 1988, 30 (04) :333-368