CLINICAL-APPLICATION OF ANTITHROMBOGENIC HYDROGEL WITH LONG POLY(ETHYLENE OXIDE) CHAINS

被引：91

作者：

NAGAOKA, S

NAKAO, A

机构：

[1] TORAY INDUSTRIES LTD,BASIC RES LABS,KAMAKURA 248,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT SURG 2,NAGOYA,AICHI 464,JAPAN

来源：

BIOMATERIALS | 1990年 / 11卷 / 02期

关键词：

blood compatibility; Hydrogels; poly(ethylene oxide);

D O I：

10.1016/0142-9612(90)90126-B

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Thirty clinical tests on PVC drain tubes coated with hydrophilic copolymer with long poly(ethylene oxide) chains (PEO-COAT®) were carried out. Controls were non-coated PVC drain tubes. Thrombogenesis was observed in 24 out of 30 non-coated PVC drain tubes (80%) and in only 4 out of 30 PEO-COAT drain tubes (13%). PEO-COAT drain tubes significantly suppressed absorption of plasma proteins and adhesion of platelets. The excellent antithrombogenic property of this hydrophilic polymer, already suggested by in vitro and in vivo experiments, was demonstrated here clinically. © 1990.

引用

页码：119 / 121

页数：3