CHIRAL SEPARATION OF N-AMINOALKYLSUCCINIMIDES ON AN ALPHA-1-ACID GLYCOPROTEIN COLUMN - A QUANTITATIVE STRUCTURE ENANTIOSELECTIVITY RELATIONSHIP STUDY

被引：21

作者：

NORINDER, U

HERMANSSON, J

机构：

[1] ASTRA RES CTR AB,SODERTALJE,SWEDEN

[2] CHROMTECH AB,NORSBORG,SWEDEN

来源：

CHIRALITY | 1991年 / 3卷 / 05期

关键词：

CHIRAL-AGP; HPLC; PLS; PRINCIPAL COMPONENTS;

D O I：

10.1002/chir.530030508

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two quantitative structure-enantioselectivity models have been developed for a series of N-aminoalkylsuccinimides using the statistical method PLS. The models permit the prediction of enantioselectivity on an alpha-1-acid glycoprotein column. The models are based on a physicochemical description of the structures.

引用

页码：422 / 426

页数：5

共 15 条

[1] SEPARATION OF THE ENANTIOMERS OF BETA-RECEPTOR BLOCKING-AGENTS AND OTHER CATIONIC DRUGS USING A CHIRAL-AGP COLUMN - BINDING-PROPERTIES AND CHARACTERIZATION OF IMMOBILIZED ALPHA-1-ACID GLYCOPROTEIN [J].