NEW METHODS AND REAGENTS IN ORGANIC-SYNTHESIS .96. STEREOSELECTIVE SYNTHESIS OF 2,3-DIHYDROXY-4-DIMETHYLAMINO-5-METHOXYPENTANOIC ACID, A FRAGMENT OF CALYCULINS - DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF CALYCULINS

被引：53

作者：

HAMADA, Y

TANADA, Y

YOKOKAWA, F

SHIOIRI, T

机构：

[1] Faculty of Pharmaceutical Sciences, Nagoya City University Tanabe-dori, Mizuho-ku, Nagoya

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)79444-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,3-Dihydroxy-4-dimethylamino-5-methoxypentanoic acid (2) with (2R,3R,4R)-configuration has been stereoselectively prepared from (S)-pyroglutaminol (3) and revealed to be the enantiomer of the compound derived from calyculins (1), which provides the conclusive evidence on the absolute configuration of calyculins.

引用

页码：5983 / 5986

页数：4

共 23 条

[1] TRIPLE ASYMMETRIC-SYNTHESIS FOR FRAGMENT ASSEMBLY - VALIDITY OF APPROXIMATE MULTIPLICATIVITY OF THE 3 DIASTEREOFACIAL SELECTIVITIES [J].