CARBOXY-TERMINAL-EXTENDED VARIANT OF THE HUMAN FIBRINOGEN ALPHA-SUBUNIT - A NOVEL EXON CONFERRING MARKED HOMOLOGY TO BETA-SUBUNIT AND GAMMA-SUBUNIT

被引:68
作者
FU, YP [1 ]
WEISSBACH, L [1 ]
PLANT, PW [1 ]
ODDOUX, C [1 ]
CAO, Y [1 ]
LIANG, TJ [1 ]
ROY, SN [1 ]
REDMAN, CM [1 ]
GRIENINGER, G [1 ]
机构
[1] NEW YORK BLOOD CTR, LINDSLEY F KIMBALL RES INST, NEW YORK, NY 10021 USA
关键词
D O I
10.1021/bi00163a002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Similarities between the N-terminal regions of the three subunits of the clotting protein fibrinogen-(alphabetagamma)2-suggest that they evolved from a common progenitor. However, to date no human alpha chain has been found with the strong C-terminal homology shared by the beta and gamma chains. Here we examine the natural product of a novel fibrinogen alpha chain transcript bearing a separate open reading frame that supplies the missing C-terminal homology to the other chains. Additional splicing leads to the use of this extra sequence as a sixth exon elongating the alpha chain by 35%. Since the extended alpha chain (alphaE) is assembled into fibrinogen molecules and its synthesis is enhanced by interleukin-6, it suggests participation in both the acute phase response and normal physiology.
引用
收藏
页码:11968 / 11972
页数:5
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