AUTOANTIBODIES TO CHROMATIN COMPONENTS IN JUVENILE RHEUMATOID-ARTHRITIS

被引：32

作者：

BURLINGAME, RW

RUBIN, RL

ROSENBERG, AM

机构：

[1] SCRIPPS RES INST, DEPT MOLEC & EXPTL MED, LA JOLLA, CA USA

[2] UNIV SASKATCHEWAN, PEDIAT RHEUMAT DIS RES LAB, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 06期

关键词：

D O I：

10.1002/art.1780360615

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To characterize autoantibodies to chromatin components in patients Methods. The sera of 50 children with JRA were analyzed for antinuclear antibodies (ANA) by immunofluorescence and enzyme-linked immunosorbent assay (ELISA) techniques. Results. By immunofluorescence, ANA and antibodies to high-mobility group proteins or to DNA-free histones were common in patients with pauciarticular JRA and rheumatoid factor-positive polyarticular JRA. However, reactivity with histone-DNA complexes was rare. Conclusion. Because antihistone antibodies detected by ELISA failed to bind chromatin or other histone-DNA complexes, they are not likely to represent the immunofluorescent ANA activity in serum.

引用

页码：836 / 841

页数：6

共 24 条

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Brewer E J Jr, 1977, Arthritis Rheum, V20, P195

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