ALZHEIMERS-DISEASE - A REVIEW OF RECENT FINDINGS

被引：8

作者：

LAMOUR, Y ^{[1
]}

机构：

[1] HOP LARIBOISIERE,F-75010 PARIS,FRANCE

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1994年 / 48卷 / 07期

关键词：

ALZHEIMERS DISEASE; BETA AMYLOID PROTEIN; ACETYLCHOLINE;

D O I：

10.1016/0753-3322(94)90177-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The recent development of biological research on dementias of the Alzheimer's type has lead to a better understanding of their pathophysiology. We know the nature of the proteins present in senile plaques and in the neurofibrillary degeneration. Pathophysiological hypotheses are more precise, and clearly involve genetic factors. The rapid progress in this field raises the hope that more efficient treatments will appear in the near future.

引用

页码：312 / 318

页数：7

共 15 条

[1] BRION JP, 1991, MALADIE ALZHEIMER AU, P117
[2] EARLY-ONSET ALZHEIMERS-DISEASE CAUSED BY MUTATIONS AT CODON-717 OF THE BETA-AMYLOID PRECURSOR PROTEIN GENE
CHARTIERHARLIN, MC
CRAWFORD, F
HOULDEN, H
WARREN, A
HUGHES, D
FIDANI, L
GOATE, A
ROSSOR, M
ROQUES, P
HARDY, J
MULLAN, M
[J]. NATURE, 1991, 353 (6347) : 844 - 846
[3] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES
CORDER, EH
SAUNDERS, AM
STRITTMATTER, WJ
SCHMECHEL, DE
GASKELL, PC
SMALL, GW
ROSES, AD
HAINES, JL
PERICAKVANCE, MA
[J]. SCIENCE, 1993, 261 (5123) : 921 - 923
[4] SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE
GOATE, A
CHARTIERHARLIN, MC
MULLAN, M
BROWN, J
CRAWFORD, F
FIDANI, L
GIUFFRA, L
HAYNES, A
IRVING, N
JAMES, L
MANT, R
NEWTON, P
ROOKE, K
ROQUES, P
TALBOT, C
PERICAKVANCE, M
ROSES, A
WILLIAMSON, R
ROSSOR, M
OWEN, M
HARDY, J
[J]. NATURE, 1991, 349 (6311) : 704 - 706
[5] AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE
HARDY, J
ALLSOP, D
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) : 383 - 388
[6] HAUW JJ, 1991, MALADIE ALZHEIMER AU, P24
[7] ALZHEIMERS-DISEASE - CELL-SPECIFIC PATHOLOGY ISOLATES THE HIPPOCAMPAL-FORMATION
HYMAN, BT
VANHOESEN, GW
DAMASIO, AR
BARNES, CL
[J]. SCIENCE, 1984, 225 (4667) : 1168 - 1170
[8] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR
KANG, J
LEMAIRE, HG
UNTERBECK, A
SALBAUM, JM
MASTERS, CL
GRZESCHIK, KH
MULTHAUP, G
BEYREUTHER, K
MULLERHILL, B
[J]. NATURE, 1987, 325 (6106) : 733 - 736
[9] LAMOUR Y, 1991, MALADIE ALZHEIMER AU, P153
[10] A MUTATION IN THE AMYLOID PRECURSOR PROTEIN ASSOCIATED WITH HEREDITARY ALZHEIMERS-DISEASE
MURRELL, J
FARLOW, M
GHETTI, B
BENSON, MD
[J]. SCIENCE, 1991, 254 (5028) : 97 - 99

← 1 2 →