The Hhal polymorphism in the CYP2D6 gene is not associated with Parkinson's disease in a Caucasian population

被引：4

作者：

Nicholl, DJ ^{[1
]}

Bennett, P ^{[1
]}

Ramsden, DB ^{[1
]}

Ho, SL ^{[1
]}

Williams, AC ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,QUEEN ELIZABETH HOSP,DEPT NEUROL,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 1995年 / 2卷 / 06期

关键词：

Parkinson's disease; genetics; debrisoquine hydroxylase;

D O I：

10.1111/j.1468-1331.1995.tb00178.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Polymorphisms of the CYP2D6 gene have been reported in association with susceptibility to Parkinson's disease (PD). In a Japanese population, a HhaI polymorphism in the CYP2D6 gene was associated with a 5.56-fold risk of PD (Tsuneoka et at, 1993). We investigated the frequency of this polymorphism in Caucasian patients with sporadic PD and in healthy controls. Although the frequency of the polymorphism was significantly higher in Caucasians compared with Japanese, there was no association with PD.

引用

页码：580 / 582

页数：3

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