PREPARATION AND ANTIINFLAMMATORY PROPERTIES OF SOME 1-SUBSTITUTED 3-(5-TETRAZOLYMETHYL)INODLES1 AND HOMOLOGS

被引：52

作者：

JUBY, PF

HYDYMA, TW

机构：

[1] Research Division, Bristol Laboratories, Division of Bristol-Myers Company, Syracase

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-substituted 3-(5-telrazolylmethyl)indoles and homologs were prepared as tetrazole analogs of indomethaein and other indole-3-acetic acid antiinflammatory agents. Some of the products show significant antiinflammatory activity when tested orally in rats. Structure-activity relationships in this series do not correspond to those for the carboxylic acid compounds. The most active compound is 1-(4-Chlorobenzoyl)-3-(5-tetrazolylmethyl)indole. © 1969, American Chemical Society. All rights reserved.

引用

页码：396 / +

页数：1

共 27 条

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