REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC INVESTIGATION OF LEVODOPA PREPARATIONS .2. LEVODOPA DETERMINATION

被引:10
作者
SCHIEFFER, GW
机构
[1] Pharmaceutical Research Division, Norwich-Eaton Pharmaceuticals, Division of Morton-Norwich Products, inc., Norwich, New York
关键词
Antiparkinsonian agents—levodopa; high‐performance liquid chromatographic analysis; commercial preparations; impurities; degradation products; High‐performance liquid chromatography—analysis; levodopa; Levodopa—analysis; high‐performance liquid chromatography;
D O I
10.1002/jps.2600681027
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A reversed‐phase high‐performance liquid chromatographic procedure with UV detection at 280 nm is presented for levodopa determination in pharmaceutical preparations. The method is fast and specific for levodopa in the presence of its most likely impurities and degradation products. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:1299 / 1301
页数:3
相关论文
共 14 条
[1]   SYNTHESES OF 5,6-DIHYXYINDOLE AND SOME OF ITS DERIVATIVES [J].
BENIGNI, JD ;
MINNIS, RL .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :387-&
[2]   APPLICATIONS OF PAIRED ION HIGH-PRESSURE LIQUID-CHROMATOGRAPHY TO CATECHOLAMINES AND PHENYLEPHRINE [J].
GHANEKAR, AG ;
DASGUPTA, V .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (09) :1247-1250
[3]   ELECTROCHEMICAL STUDIES OF OXIDATION PATHWAYS OF CATECHOLAMINES [J].
HAWLEY, MD ;
TATAWAWA.SV ;
PIEKARSK.S ;
ADAMS, RN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (02) :447-&
[4]   THE CHEMISTRY OF ADRENOCHROME AND RELATED COMPOUNDS [J].
HEACOCK, RA .
CHEMICAL REVIEWS, 1959, 59 (02) :181-237
[5]   IMPROVED METHOD FOR ASSAY OF DOPA [J].
JOHNSON, JC ;
GOLD, GJ ;
CLOUET, DH .
ANALYTICAL BIOCHEMISTRY, 1973, 54 (01) :129-136
[6]   DETERMINATION OF DOPA IN PHARMACEUTICAL DOSAGE FORMS BASED ON OXIDATION AT TUBULAR CARBON ELECTRODE [J].
MASON, WD .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1973, 62 (06) :999-1001
[7]  
MATTOK GL, 1964, CAN J CHEM, V42, P481
[8]  
RIGGIN RM, 1976, CLIN CHEM, V22, P782
[9]   REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC INVESTIGATION OF LEVODOPA PREPARATIONS .1. AMINO-ACID IMPURITIES [J].
SCHIEFFER, GW .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (10) :1296-1298
[10]  
SCHIEFFER GW, ANAL CHEM