EFFECTS OF THE 5-HT2 RECEPTOR ANTAGONIST, RITANSERIN, ON BIOGENIC-AMINES IN THE RAT NUCLEUS-ACCUMBENS

被引：28

作者：

DEVAUD, LL

HOLLINGSWORTH, EB

机构：

[1] Wellcome Research Laboratories, Research Triangle Park, NC 27709

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 03期

关键词：

RITANSERIN; 5-HT2 RECEPTOR ANTAGONISTS; MICRODIALYSIS; DOPAMINE;

D O I：

10.1016/0014-2999(91)90235-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of acute ritanserin treatment on dopamine (DA) and serotonin (5-HT) release and metabolism were studied in tissue and microdialysis samples of the nucleus accumbens in rats. Administration of a moderate dose of ritanserin elicited decreases in DA and 5-HT in tissue with concomitant increases in extracellular fluid. These data show that selective 5-HT2 receptor antagonism modulates DA as well as 5-HT neurotransmission and adds support to the suggestion that 5-HT/DA interactions may be important in the treatment of psychoses.

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收藏

页码：427 / 429

页数：3

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