THE COMPLETE AMINO-ACID-SEQUENCE OF THE SHORTER FORM OF HUMAN BASIC FIBROBLAST GROWTH-FACTOR RECEPTOR DEDUCED FROM ITS CDNA

We have isolated a full-length cDNA for human basic fibroblast growth factor (bFGF) receptor-like protein from a human placenta cDNA library. Determination of the nucleotide sequence of the cDNA allows elucidation of the complete amino acid sequence of the receptor (731 amino acids) which has two extracellular immunoglobulin-like domains, a transmembrane domain and an intracellular tyrosine kinase domain. The receptor has remarkable amino acid similarity (98 % identity) to the shorter form of murine bFGF receptor reported recently (H.H.Reid et al. (1990) Proc. Natl. Acad. Sci. USA 87, 1596 - 1600). The receptor described here is expected to be the shorter form of human bFGF receptor. © 1990.